Tolnaftate was synthesized in the early 1950s and is classified as a small molecule. It was first prescribed as an Rx drug for fifteen years. After millions of doses were administered, with only a statistically insignificant incidence of minor adverse reactions (pruritis and skin irritation), Tolnaftate was classified as a Category 1 GRASE (Generally Recognized As Safe and Effective) drug. As a result of its efficacy and safety, the FDA approved tolnaftate as a topical antifungal OTC in 1965. In …Read More